The goal of the Penninger Lab is to develop new and effective treatments for diseases by uncovering the fundamental biological principles underlying development and disease. To accomplish these goals, the lab develops and deploys a broad range of in vitro and in vivo tools that reveal the fundamental mechanisms involved in human disease. These approaches include genetic editing in vitro and in vivo, human-induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, mouse and human organoid cultures, and genetically engineered mice. The lab’s multidisciplinary techniques enable them to model and study the complexity of diseases.