Research Theme:
Cellular & Molecular Engineering, Imaging and Computational Biology,Research Interests:
genome editing; cell engineering; mouse genetics; high-performance computing to trace molecular & cellular dynamics in high-resolution; DNA event recording; cell lineage tracing; stem cell; synthetic biology
Biography:
The Yachie laboratory is developing “DNA event recording” technologies, by which high-resolution molecular and cellular information of individual cells in a multicellular organism can be progressively stored in cell-embedded synthetic “DNA tapes.” Thus, at the time of observation, such a system allows the readout of historical molecular and cellular information of many cells using high-throughput DNA sequencing. Harnessing genome editing, cell engineering, mouse genetics, and high-performance computing, Dr. Yachie and his research team aim to establish “Sense,” “Write,” “Store,” and “Read” technologies for the massive tracing of molecular and cellular dynamics in high-resolution.
RESEARCH EXCELLENCE
Our research group pioneers platform technologies for biology, including cutting-edge genome editing tools (Science 2016, Science 2018, Nature Biotechnology 2020, Cell 2023). We advance cells and animal models with enhanced functions (Science 2022), deepening our understanding of the human body and addressing disorders. Additionally, we’re active in laboratory automation to expedite life science research and biotechnology development.