Associate Professor, School of Biomedical Engineering

 

Research Interests:

While early mammalian embryogenesis can be observed at the single-cell resolution under a microscope, a cell division lineage of whole-body development is yet to be resolved. The continuous turnover and response of cells during homeostasis, as well as in many disorders, also remain unclear. At present, no technology enables efficient analysis of dynamic changes in molecular profiles and cellular behaviors in complex biological systems. The Yachie laboratory is developing “DNA event recording” technologies, by which high-resolution molecular and cellular information of individual cells in a multicellular organism can be progressively stored in cell-embedded synthetic “DNA tapes.” Thus, at the time of observation, such a system allows the readout of historical molecular and cellular information of many cells using high-throughput DNA sequencing. Harnessing genome editing, cell engineering, mouse genetics, and high-performance computing, Dr. Yachie and his research team aim to establish “Sense,” “Write,” “Store,” and “Read” technologies for the massive tracing of molecular and cellular dynamics in high-resolution.

For more information about Dr. Yachie’s research, please visit Google Scholar.