Professor, Department of Cellular & Physiological Sciences
Member, Djavad Mowafaghian Center for Brain Health

 

Other Affiliation: Cellular & Physiological Sciences

 

Research Areas:

– Understand the formation, remodelling, and elimination of synaptic connections in the brain
– Determine how disruptions in the formation and/or plasticity of synaptic connections perturb brain function
– Determine whether restoring synaptic function in the diseased brain can normalize cognitive and functional abilities

 

Research Interests:

The principle research objective of Dr. Bamji’s laboratory is to elucidate the cellular and molecular mechanisms underlying the formation, stability, and elimination of CNS synapses. The Bamji laboratory primarily utilizes cultured hippocampal neurons as a model system, and extend these studies to genetically modified mouse models when appropriate. Fundamental questions addressed in the lab include; 1) how does cell-cell contact result in the assembly of pre- and postsynaptic compartments, 2) what are the contributions of pre- and postsynaptic elements to the integrity of the synapse, 3) what are the trans-synaptic signals that regulate synaptic plasticity, and 4) is synapse elimination a stereotypical process and, if so, what is the sequence of molecular events underlying synapse disassembly? Answers to these questions will not only reveal mechanisms underlying developmental and neurodegenerative disorders, but will also provide insight into the molecular signals involved in synaptic strengthening, a process believed essential for learning and memory.

 

For more information about Dr. Bamji’s research, please visit Google Scholar.