Tim Murphy’s laboratory contributes to understanding of how the mouse cortex adapts after stroke, resulting in remapping of brain function from damaged to surviving areas using mouse models. The lab is developing new in vivo imaging and optogenetic tools that have parallels to human brain imaging and stimulation tools. They are currently developing fully automated methods of mouse brain imaging using home-cage technologies that enable remote control of experiments through the internet. The lab evaluates mesoscale functional connectivity using genetically-encoded sensors with the aim of piloting treatments for circuit-level activity imbalances that accompany diseases of the nervous system. These tools enable 24 h/day monitoring of sensory-motor function in mouse home cages.